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IMPORTANT SAFETY INFORMATION AND INDICATIONS 

WARNING: SUICIDALITY AND DEATH  

BONERMAX may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed.  Watch for these changes and call your healthcare provider right away if you notice new or sudden changes such as vanishing fingerprints, behavior issues, blue urine, or creepy feelings, especially if severe. Pay particular attention to such changes when BONERMAX is started or when the dose is increased.  

Do not take BONERMAX if you:  Take a Monoamine Oxidase Inhibitor (MAOI), including linezolid or methylene blue, or if you stopped taking an MAOI in the last 2 weeks. Do not take an MAOI within 2 weeks of stopping BONERMAX. Ask your doctor or pharmacist if you are not sure if your medicine is an MAOI Take Orap® (pimozide) because this can cause serious heart problems  

Call a doctor right away if you or a person you know who is taking BONERMAX has any of the following symptoms, especially if they are new, worse, or worry you:  

Attempts to commit suicide 

Acting aggressive or violent 

New or worse depression 

Feeling agitated, restless, angry, or irritable 

An increase in activity or talking more than what is normal for you 

Acting on dangerous impulses 

Thoughts about suicide or dying 

New or worse anxiety or panic attacks 

Trouble sleeping 

Other unusual changes in behavior or mood 

Death

Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. 

Before taking  BONERMAX, ask your doctor and pharmacist about all prescription and over-the-counter medications and supplements you take or plan to take, including those to treat migraines, psychiatric disorders (including antidepressants or amphetamines) to avoid a potentially life-threatening condition called serotonin syndrome, and aspirin and other NSAID pain relievers or other blood thinners because they may increase the risk of bleeding.  

Tell your doctor immediately if you become severely ill and have some or all of these symptoms including Death: 

Agitation, hallucinations, coma, or other changes in mental status; coordination problems or muscle twitching (overactive reflexes); racing heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting, or diarrhea; muscle tightness, as these may be the symptoms of a life-threatening condition called Serotonin Syndrome 

Have a rash, hives, swelling, or trouble breathing as these may be the symptoms of an allergic reaction 

Have seizures or convulsions 

Have any increased or unusual bruising or bleeding, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin